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Filtered Search Results
Ambeed AMBEED
5000950354 5-METHYLQUINOLINE-3-CARBO 10MG
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Apexbio Technology LLC NSC 74859 501919-59-1 200mg
NSC 74859 (CAS 501919-59-1) also known as S3I-201 is a selective inhibitor of the signal transducer and activator of transcription 3 (Stat3) pathway S3I-201 disrupts Stat3 DNA-binding activity exhibiting an IC50 of 86 M in vitro with minimal inhibitory effects on Stat1 and Stat5 It also impedes the formation of Stat1-Stat3 and Stat1-Stat1 complexes with IC50 values of 160 M and 300 M respectively In NIH 3T3/v-Src fibroblasts S3I-201 reduces constitutive Stat3 activation and pTyr-705 Stat3 levels induces apoptosis at 30 100 M and downregulates cyclin D1 Bcl-xL and survivin expression This compound is widely utilized in research to interrogate Stat3 function in cellular transformation and oncogenic signaling pathways
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Aobchem (4-Bromo-3-(morpholine-4-carbonyl)phenyl)boronic acid | 97% | C11H13BBrNO4 | 250mg
(4-Bromo-3-(morpholine-4-carbonyl)phenyl)boronic acid | 97% | C11H13BBrNO4 | 250mg
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Aobchem 2 2-Difluoroethylmethane sulfonate | ≥95% | CAS 163035-65-2 | C3H6F2O3S | 5g
2 2-Difluoroethylmethane sulfonate | ≥95% | CAS 163035-65-2 | C3H6F2O3S | 5g
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Aobchem (3-Trifluoromethylphenyl)carbamic acid tert-butyl ester | ≥95% | CAS 109134-07-8 | C12H14F3NO2 | 1g
(3-Trifluoromethylphenyl)carbamic acid tert-butyl ester | ≥95% | CAS 109134-07-8 | C12H14F3NO2 | 1g
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Aobchem 3 4-Dimethoxythiophene-2-carbaldehyde | 97% | CAS 51792-38-2 | C7H8O3S | 5g
3 4-Dimethoxythiophene-2-carbaldehyde | 97% | CAS 51792-38-2 | C7H8O3S | 5g
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Aobchem (3-Trifluoromethylphenyl)carbamic acid tert-butyl ester | ≥95% | CAS 109134-07-8 | C12H14F3NO2 | 5g
(3-Trifluoromethylphenyl)carbamic acid tert-butyl ester | ≥95% | CAS 109134-07-8 | C12H14F3NO2 | 5g
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Aobchem 3-Methylbenzothiophene-2-carboxaldehyde | ≥95% | CAS 22053-74-3 | C10H8OS | 500mg
3-Methylbenzothiophene-2-carboxaldehyde | ≥95% | CAS 22053-74-3 | C10H8OS | 500mg
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Aobchem 9-(3 5-Dibromophenyl)-9H-carbazole | ≥97% | CAS 750573-26-3 | C18H11Br2N | 25g
9-(3 5-Dibromophenyl)-9H-carbazole | ≥97% | CAS 750573-26-3 | C18H11Br2N | 25g
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Aobchem 2-Fluoro-5-(morpholine-4-carbonyl)phenylboronic acid | ≥97% | CAS 1072951-41-7 | C11H13BFNO4 | 10g
2-Fluoro-5-(morpholine-4-carbonyl)phenylboronic acid | ≥97% | CAS 1072951-41-7 | C11H13BFNO4 | 10g
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Aobchem 9-(3 5-Dibromophenyl)-9H-carbazole | ≥97% | CAS 750573-26-3 | C18H11Br2N | 10g
9-(3 5-Dibromophenyl)-9H-carbazole | ≥97% | CAS 750573-26-3 | C18H11Br2N | 10g
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Aobchem 2 2-Difluoroethylmethane sulfonate | ≥95% | CAS 163035-65-2 | C3H6F2O3S | 25g
2 2-Difluoroethylmethane sulfonate | ≥95% | CAS 163035-65-2 | C3H6F2O3S | 25g
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Aobchem 2 2-Difluoroethylmethane sulfonate | ≥95% | CAS 163035-65-2 | C3H6F2O3S | 10g
2 2-Difluoroethylmethane sulfonate | ≥95% | CAS 163035-65-2 | C3H6F2O3S | 10g
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Apexbio Technology LLC Kobe0065 436133-68-5 200mg
Kobe0065 (CAS 436133-68-5) is a small-molecule inhibitor targeting Ras proteins by disrupting the interaction between GTP-bound H-Ras or M-Ras and the Ras-binding domain of c-Raf-1 Identified via in silico screening Kobe0065 inhibits H-Ras GTP c-Raf-1 binding with a Ki of 46 M In NIH 3T3 cells it decreases the association of mutant H-RasG12V with c-Raf-1 in a dose-dependent manner (IC50 10 M) and suppresses downstream phosphorylation of MEK and ERK at 20 M In colony formation assays Kobe0065 inhibits proliferation of H-rasG12V transfected NIH 3T3 cells (IC50 0 5 M) and demonstrates activity against Ras-mutant cancer cell lines In xenograft models administration reduces tumor growth Kobe0065 serves as a research tool for studying Ras-mediated signaling and potential anti-tumor mechanisms
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Medchemexpress LLC 7-Nitroindazole | 2942-42-9 | 99.1% | C7H5N3O2 | 200 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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7-Nitroindazole | 2942-42-9 | 99.1% | C7H5N3O2 | 200 MG
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