Quinolines and derivatives
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Filtered Search Results
Medchemexpress LLC Endothelin-1 (1-31) (Human) | 133972-52-8 | 99.7% | 3628.16 | 1 MG
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Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent derived from the selective hydrolysis of big ET-1 by chymase. In vitro, it induces human mesangial cell proliferation and ERK activation. In vivo, it induces contraction in the mouse mesenteric artery, possibly mediated by the ETA receptor. This contraction can be increased by aging, and gender differences have been observed in chronic diabetic conditions.
- Potent vasoconstrictor.
- Hypertensive agent.
- Derived from selective hydrolysis of big ET-1 by chymase.
- Induces human mesangial cell proliferation and ERK activation in vitro.
- Induces contraction in mouse mesenteric artery in vivo.
- Possible ETA receptor mediation.
- Effects can be increased by aging.
- Gender differences observed in chronic diabetic conditions.
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Medchemexpress LLC Chlormezanone | 80-77-3 | 99.8% | 200 MG
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Chlormezanone resembles benzodiazepine, and its action is similar to benzodiazepine-type agents. It is used as an anxiolytic and a muscle relaxant.
- Used as an anxiolytic and a muscle relaxant.
- Resembles benzodiazepine and acts similarly to benzodiazepine-type agents.
- Available in solid form (white to off-white).
- For research use only.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000428337 SULFO-CY3 AMINE 25MG
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Medchemexpress LLC Oxaliplatin | 61825-94-3 | 99.99% | 397.29 | 200 MG
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Oxaliplatin is an analytical standard and DNA synthesis inhibitor. It induces DNA crosslinking damage, preventing DNA replication and transcription, and ultimately leading to apoptosis. This product is intended for various research and analytical applications, particularly in cancer research.
- DNA synthesis inhibitor
- Causes DNA crosslinking damage
- Prevents DNA replication and transcription
- Induces apoptosis
- Suitable for cancer research
- Analytical standard grade for reference assays
- Used in qualitative, quantitative, and methodological research experiments
- Applicable in techniques such as HPLC, GC, and MS
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Medchemexpress LLC Ulixertinib (Standard) | 869886-67-9 | 99.9% | 433.33 | 200 MG
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Ulixertinib is a potent, orally active, and highly selective ATP-competitive, reversible covalent inhibitor of ERK1/2 kinases. It effectively inhibits ERK2 with an IC50 of <0.3 nM, reducing phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) activity in A375 melanoma cells.
- Potent, orally active, and highly selective
- ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases
- Inhibits ERK2 with an IC50 of <0.3 nM
- Reduces phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) activity
- Demonstrates antiproliferative activity in various cell lines
- Investigated in clinical trials for multiple conditions, including solid tumors and various cancers
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Apexbio Technology LLC GSK1838705A 1116235-97-2 200mg
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GSK1838705A (CAS 1116235-97-2) is a small molecule inhibitor targeting the kinase activity of insulin-like growth factor-1 receptor (IGF-1R) insulin receptor and anaplastic lymphoma kinase (ALK) It exhibits potent inhibition with IC50 values of 2 0 nM for IGF-1R 1 6 nM for insulin receptor and 0 5 nM for ALK In preclinical research GSK1838705A suppresses proliferation of hematologic malignancy-derived tumor cells including multiple myeloma and Ewing sarcoma lines and inhibits tumor xenograft growth in vivo Additionally despite targeting the insulin receptor it minimally affects glucose homeostasis at effective doses Due to its multi-target kinase inhibitory profile GSK1838705A serves as a promising tool for cancer biology research
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Apexbio Technology LLC JNJ-26481585 875320-29-9 200mg
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JNJ-26481585 (CAS 875320-29-9) is a small-molecule inhibitor targeting class I histone deacetylases (HDACs) specifically HDAC1 HDAC2 and HDAC3 with reported IC50 values of 0 11 0 33 and 4 8 nM respectively It exhibits potent anti-proliferative activity across various human cancer cell lines including lung breast colon prostate ovarian and brain cancers (IC50 range 3 1 246 nM) Mechanistically JNJ-26481585 induces histone H3 acetylation alleviates HDAC-mediated repression of the p21waf1 cip1 promoter and promotes apoptosis in colorectal cancer cell models Consequently this compound serves as a research tool for cancer epigenetics and therapeutic assessment
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Medchemexpress LLC 6,8-Diprenylorobol | 66777-70-6 | 1 MG
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6,8-Diprenylorobol is a prenylated isoflavone isolated from the leaves of *Cudrania tricuspidata*. It exhibits an antiproliferative effect and induces apoptosis by activating p53 and generating reactive oxygen species (ROS). It has shown to inhibit proliferation in LoVo and HCT15 cells in a dose- and time-dependent manner and also regulates MAPKs.
- Exhibits antiproliferative effect
- Induces apoptosis by activating p53
- Generates reactive oxygen species (ROS)
- Inhibits proliferation in LoVo and HCT15 cells
- Regulates MAPKs in LoVo and HCT15 cells
- Increases ROS levels in LoVo and HCT15 cells
- Inhibits LPS-induced nitric oxide production in RAW264.7 cells
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Medchemexpress LLC Hydroquinidine | 1435-55-8 | 99.97% | 5 G
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Hydroquinidine (Dihydroquinidine) is a potent ion channel blocker that exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. It also prolongs the QT interval and demonstrates antiarrhythmic efficacy.
- Potent ion channel blocker
- Strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells
- Prolongs the QT interval
- Antiarrhythmic efficacy
- For research use only
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Apexbio Technology LLC AS 602801 848344-36-5 200mg
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AS 602801 (CAS 848344-36-5) is a selective small-molecule inhibitor targeting c-Jun N-terminal kinase (JNK) a kinase implicated in immune and apoptotic signaling pathways Preclinical studies indicate that AS 602801 suppresses T-cell proliferation and promotes apoptosis altering gene expression in RRMS-derived CD4 and CD8 T-cells and innate receptor expression in RRMS-associated CD11b cells Animal models show beneficial effects in autoimmune disorders and neuronal apoptosis scenarios Thus AS 602801 is investigated primarily for therapeutic potential in multiple sclerosis and fibrotic conditions
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eMolecules 288154-18-7 | tert-butyl 4-amino-4-carbamoylpiperidine-1-carboxylate | Synthonix | MFCD04114477 | 243.307 | C11H21N3O3 | 97.000 | CC(C)(C)OC(=O)N1CCC(N)(CC1)C(N)=O | 10g | 808568735
tert-butyl 4-amino-4-carbamoylpiperidine-1-carboxylate | Synthonix | 288154-18-7 | MFCD04114477 | 243.307 | C11H21N3O3 | 97.000 | CC(C)(C)OC(=O)N1CCC(N)(CC1)C(N)=O | 10g | 808568735
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Ambeed | (7-(Trifluoromethyl)quinoline-3-carboxylic acid | 1 g | A512878-1g| Purity: 97% | 71082-51-4 | MFCD11042923 | MW: 241.17
Ambeed | (7-(Trifluoromethyl)quinoline-3-carboxylic acid | 1 g | A512878-1g| Purity: 97% | 71082-51-4 | MFCD11042923 | MW: 241.17
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Medchemexpress LLC DTPD-Q | 252950-56-4 | 99.7% | 318.37 | 100 MG
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DTPD-Q is the transformation product (TATPs) of the tire additive N,N′-diphenyl-p-phenylenediamine (DTPD). It accumulates and raises ecological risk in the environment.
- For research use only.
- Appearance: Solid, yellow to brown.
- Solubility: DMSO : 2 mg/mL (6.28 mM; ultrasonic and warming and heat to 60°C; hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO).
- Storage: Powder -20°C 3 years, 4°C 2 years. In solvent -80°C 6 months, -20°C 1 month.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000377764 X-GAL 200MG
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Chem-Impex International, Inc. 8-Hydroxyquinoline | 148-24-3 | MFCD00006807 | 100G
8-Hydroxyquinoline, 148-24-3, MFCD00006807, 100G
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